WebPHF8 Promotes Migration and Invasion of ESCC Cells in vitro Cancer cells acquire certain biological capabilities such as invasion and metastasis during the multistep development of tumors. ESCC is one of the most aggressive cancers, and its metastasis is a critical determinant of a poor prognosis. WebThe PHF8 gene provides instructions for making a protein that is found in the cell nucleus, particularly in brain cells before and just after birth. The PHF8 protein is part of a group known as zinc finger proteins, which contain one or …
Novel oncogenic roles and regulations of histone demethylase PHF8 …
WebPHF8-knockout cells showed a marked increase in sensitivity to HU or CPT . Also, PHF8-knockout cells were more vulnerable in the presence of cisplatin , a well-known … WebAug 15, 2014 · PHF8 is a JmjC domain-containing protein and erases repressive histone marks including H4K20me1 and H3K9me1/2. It binds to H3K4me3, an active histone mark usually located at transcription start sites (TSSs), through its plant homeo-domain, and is thus recruited and enriched in gene promoters. PHF8 is involved in the development of … bypass payment wall
High-fat diet fuels prostate cancer progression by rewiring the ...
WebOct 11, 2013 · Recently, PHF8 was found to have an effect on prostate cancer cell proliferation, migration, and invasion, in which the integrin pathway is linked to its … WebSep 25, 2024 · Along this line, PHF8 has been documented in cell culture systems as a MYC transcriptional coactivator 35 and a regulator of prostate cancer cell proliferation, migration and invasion 36, 43,... WebPHF8 expression is elevated in HER2+ breast cancers and is upregulated by HER2. Prompted by our previous findings of higher expression of PHF8 in HER2+ breast cancer cells and its functional requirement in the anchorage-independent growth of these cells (Shao et al, 2024), we first evaluated . PHF8 clothes for trip