Cyclobutane dimer

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August undefined, 2024

WebApr 13, 2024 · INTRODUCTION. Cyclobutane pyrimidine dimers (CPDs) (Figure 1A) are the major DNA photoproducts induced by sunlight and are responsible for the majority of C to T and CC to TT mutations leading to skin cancer ().Because CPDs do not distort DNA structure very much, they are repaired with a half life of about 24 h in human cells, which … WebDec 1, 1992 · Flavin-photosensitized monomerization of dimethylthymine cyclobutane dimer: remarkable effects of perchloric acid and participation of excited-singlet, triplet, and chain-reaction pathways. Chyongjin Pac, Kunihito Miyake, Yasuhiro Masaki, Shozo Yanagida, Takeshi Ohno, and ; Akio Yoshimura

On the photoproduction of DNA/RNA cyclobutane pyrimidine dimers …

WebJun 14, 1996 · The REV3 and REV7 genes of the yeast Saccharomyces cerevisiae are required for DNA damage-induced mutagenesis. The Rev3 and Rev7 proteins were shown to form a complex with DNA polymerase activity. This polymerase replicated past a thymine-thymine cis-syn cyclobutane dimer, a lesion that normally severely inhibits replication, … WebDec 1, 1992 · Flavin-photosensitized monomerization of dimethylthymine cyclobutane dimer: remarkable effects of perchloric acid and participation of excited-singlet, triplet, … harbour house gorey

Recognition and repair of the cyclobutane thymine dimer, a ... - PubMed

WebEthene dimer Biethylene Diethylene. Identifiers CAS Number. ... Cyclobutane is a cycloalkane and organic compound with the formula (CH 2) 4. Cyclobutane is a colourless gas and commercially available as a liquefied gas. … Webmatically repair cyclobutane pyrimidine dimer lesions are much more sensitive to the cytotoxic effects of ultraviolet light than are cells that can remove the dimers from their DNA (4). Moreover, recent studies show that almost all the ultraviolet light-induced mutations in Escherichia coli lac i gene occur at potential pyrimidine dimer sites ... WebOct 15, 2003 · The cyclobutane thymine dimer is the major DNA lesion induced in human skin by sunlight and is a primary cause of skin cancer, the most prevalent form of cancer in the Northern Hemisphere. In humans, the only known cellular repair mechanism for eliminating the dimer from DNA is nucleotide excision r … chandler\u0027s hibid

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Recognition and repair of the cyclobutane thymine dimer, a major …

A 6–4 photoproduct (6–4 pyrimidine– pyrimidone or 6–4 pyrimidine–pyrimidinone) is an alternate dimer consisting of a single covalent bond between the carbon at the 6 position of one ring and carbon at the 4 position of the ring on the next base. [9] This type of conversion occurs at one third the … See more Pyrimidine dimers are molecular lesions formed from thymine or cytosine bases in DNA via photochemical reactions, commonly associated with direct DNA damage. Ultraviolet light (UV; particularly UVB) … See more A cyclobutane pyrimidine dimer (CPD) contains a four membered ring arising from the coupling of the two double-bonded carbons of each of the pyrimidines. Such dimers interfere with base pairing during DNA replication, leading to mutations. See more Translesion polymerases frequently introduce mutations at pyrimidine dimers, both in prokaryotes (SOS mutagenesis) and in eukaryotes. Although the thymine-thymine CPDs … See more A study by Hanson suggests sunscreen that penetrates into the skin and thereby amplifies the amount of free radicals and oxidative stress contributes to the formation of … See more Due to the excellent photochemical properties of DNA, this nature-made molecule is damaged by only a tiny fraction of the absorbed photons. DNA transforms more than 99.9% of the photons into harmless heat (but the damage from the … See more Pyrimidine dimers introduce local conformational changes in the DNA structure, which allow recognition of the lesion by repair enzymes. In most organisms (excluding See more Direct DNA damage is reduced by sunscreen. This prevents sunburn. When the sunscreen is at the surface of the skin, it filters the UV rays, which attenuates the intensity. Even when the sunscreen molecules have penetrated into the skin, they protect against … See more WebJan 1, 2016 · The formation of cyclobutane dimers is dependent on the wavelength of the radiation. At 280 nm it is induced almost five times as efficiently as at 240 nm. At 272 nm … chandler\\u0027s hibidWebMar 17, 2024 · A major lesion caused by the most harmful UV light (UVB and UVC) is the cyclobutane pyrimidine dimer (CPD) 2. CPDs disrupt the DNA double-helical structure … chandler\\u0027s hamburgers history

"WebMar 17, 2024 · A major lesion caused by the most harmful UV light (UVB and UVC) is the cyclobutane pyrimidine dimer (CPD) 2. CPDs disrupt the DNA double-helical structure and block DNA and RNA polymerases, ... " - Cyclobutane dimer

On the photoproduction of DNA/RNA cyclobutane pyrimidine dimers …

Recognition and repair of the cyclobutane thymine dimer, a ... - PubMed

Cyclobutane dimer

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