Cisplatin induced cardiotoxicity

Author: nneb

August undefined, 2024

WebIn Cisplatin group, cardiac muscle fibers appeared disorganized, disrupted or degenerated with pyknotic nuclei and showed a significant rise in the number of anti-P53 positive nuclei. Significant increments in the percent area of collagenous fibers and TNF-α immune-expression were observed. WebApr 14, 2024 · While the exact mechanisms underlying the relationship between gut microbiota and chemotherapy-induced cardiotoxicity are not yet fully understood, these findings suggest that targeting the microbiome may be a promising strategy for mitigating the cardiovascular side effects of cancer treatment. ... observed that cisplatin, one of the ...

Cisplatin-induced cardiotoxicity with midrange ejection …

WebSep 15, 2024 · Cisplatin's side effects primarily include nephrotoxicity, gastrointestinal toxicity, neurotoxicity and ototoxicity. Cardiotoxicity is generally not defined as a side effect of cisplatin. However, over the past decade there has been a surge in the amount of clinical cases reporting a vast array of cardio-toxic events occurring during or shortly ... WebApr 4, 2024 · Hesperidin (HES) is an abundant and economical dietary bioflavonoid, and it has several pharmacological properties such as antioxidant activity and powerful cardiac protection. However, HES protection against cisplatin (CP)-induced cardiotoxicity and its mechanism have not been fully clarified. trustslayer

Cardioprotective effect of zingerone against oxidative stress ... - PubMed

WebJul 27, 2016 · Take for example the side effects of anticancer treatments: just a few years ago, side effects such as cardiotoxicity and myelotoxicity often forced the interruption of life-saving treatments. ... Callejo and colleagues examined in depth the state of art of cisplatin-induced ototoxicity. In addition to peripheral neurotoxicity, cisplatin ... WebNov 26, 2024 · 2. Chemotherapy-Induced Toxicity and Free Radicals. Mitochondria is one of the key contributors to cancer development and progression. Most of the O 2 • − generated under physiological conditions are efficiently converted into H 2 O 2 by superoxide dismutase (SOD). Catalase, glutathione peroxidase (GSH-Px, eight … WebMar 21, 2024 · Cisplatin (CP) kills tumour cells by inducing senescence or triggering innate apoptotic pathways that cause irreparable DNA damage, and it is the most commonly used first-line drug for cancer treatment. 1 However, its clinical use is often limited by dose-related cardiotoxicity, 2 which includes arrhythmias, 3 angina pectoris, 4 and cardiac … trusts login

Chemotherapy-induced cardiomyopathy caused by Pemetrexed

Hesperidin protects against cisplatin-induced …

WebCardiotoxicity has also been linked to cisplatin treatment. The leakages of lactate dehydrogenase (LDH) as well as creatine kinase from the cardiac myocytes result from Cardiotoxicity. 39 This could be secondary processes that results from cisplatin-induced lipid peroxidation or cardiac membranes. WebJun 1, 2013 · At present, no data is provided explaining the mechanism of NO in cisplatin-induced cardiotoxicity. It has been found that NO and its metabolites, including … trust smith \u0026 company 会社説明資料WebApr 14, 2024 · While the exact mechanisms underlying the relationship between gut microbiota and chemotherapy-induced cardiotoxicity are not yet fully understood, … trusts lawyer michigan livonia

"WebJan 10, 2011 · Abstract. Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that limits the clinical use of cisplatin as an anti-tumoral drug. Our study … " - Cisplatin induced cardiotoxicity

Cisplatin induced cardiotoxicity

Modulation of Oxidative Stress by Ozone Therapy in the …

WebOct 1, 2024 · Cardiotoxicity of chemotherapy exerts as the main hurdle for prognosis, while whether cisplatin causes severe cardiotoxicity remains largely unknown. Accum … WebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application (Yu et al., 2024; Deng et al., 2024). Cisplatin can cause an increase in the expression of NF-κB and TNF-α in the liver and kidney (Park et al., 2024

Did you know?

WebDec 1, 2024 · Cisplatin is a highly effective antitumor agent. However, its use is limited due to severe adverse effects, particularly nephrotoxicity, which occurs in approximately 30% of patients. There is a need for novel renoprotective compounds. WebAug 17, 2024 · Cisplatin-induced cardiotoxicity has been reported to mainly include arrhythmia, acute myocardial infarction, supraventricular tachycardia, and atrial fibrillation …

WebCardiotoxicity has been well documented as a side effect of cisplatin (CDDP) treatment. The inflammatory response plays a crucial role in the pathological process of CDDP … WebLung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in …

WebHowever, it has a wide variety of side effects such as hepato, gastrointestinal, neuro, nephro, and cardiotoxicity (acute and/or chronic) th … The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs mediated pectin in the treatment of cisplatin-induced cardiotoxicity in experimental rats WebMar 21, 2024 · However, HES protection against cisplatin (CP)-induced cardiotoxicity and its mechanism have not been fully clarified. The current study was performed to …

WebAug 17, 2024 · Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-α-AP-1 Signal Pathway Front Pharmacol. 2024 Aug 17;12:711238. doi: 10.3389/fphar.2024.711238. eCollection 2024. Authors

WebSecondary prevention of anthracycline-induced cardiotoxicity has also gathered quite some scientific interest. Beta-blockers, aldosterone antagonists, angiotensin receptor blockers, angiotensin converting enzyme inhibitors, neurohormonal blocking drugs and implantable devices have and may still all be used. philip sayce torrentWebAug 31, 2024 · However, the mechanism of CDDP-induced cardiotoxicity is poorly understood. Acetyl-l-carnitine (ALCAR) is an antioxidant agent with protective effects against the side effects of various chemotherapeutics. CDDP-induced cardiotoxicity and the protective role of ALCAR were evaluated in this study. philip sayce scorched earthWebQuercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway Authors Shih-Hao Wang 1 2 , Kun-Ling Tsai 3 4 , Wan-Ching Chou 3 , Hui-Ching Cheng 3 , Yu-Ting Huang 3 , Hsiu-Chung Ou 5 , Yun-Ching Chang 6 Affiliations trusts like standard oil became large mostlyWebMay 9, 2024 · Busulfan-induced pulmonary injury; Cardiotoxicity of cancer chemotherapy agents other than anthracyclines, HER2-targeted agents, and fluoropyrimidines ... et al. … trusts lawWebFeb 21, 2024 · Cardiotoxicity of trastuzumab and other HER2-targeted agents; Cisplatin nephrotoxicity; Clinical manifestations, diagnosis, and treatment of anthracycline-induced cardiotoxicity; Drug-induced thrombotic microangiopathy (DITMA) Endocrine therapy … trustsmith.net philip sayer actorWebCancer therapy can result in cardiac toxicity, such as cardiomyopathy. Cardiotoxicity with chemotherapeutic agents in the form of cardiomyopathy was first described in 1966 in patients receiving anthracyclines. 1 However, cancer treatment–induced arrhythmia (CTIA) has not attracted specific attention until recently. 2. philip sayer actor death